All About Alpha-Lipoic Acid

Alpha-lipoic acid (ALA) occurs naturally in the body and plays a crucial role in the energy-producing structures of cells. At the molecular level, it binds to protein and functions as a cofactor for several important mitochondrial enzymes. Although the majority of alpha-lipoic acid produced by the body is used almost entirely to generate energy, researchers have found that ALA may act as an antioxidant when incorporated into the diet.

Taken in supplement form, alpha-lipoic acid may defend the body against free radicals and single action molecules which can damage cells and lead to degenerative disorders associated with diminished health and aging. Other common and scientific names for alpha-lipoic acid include ALA, biletan, lipoic acid, lipoicin, thioctacid, thioctan and thioctic acid.

Sources of alpha-lipoic acid

Alpha-lipoic acid is synthesized in both animals and humans. But because little “free” alpha-lipoic acid is left circulating in the body after cells use it for energy, external sources of ALA are needed to produce an antioxidant effect. These include meats and select vegetables (such as spinach) and dietary supplements that contain alpha-lipoic acid.

How ALA works in the body

Alpha-lipoic acid, recognized for its antioxidant potential in the late 1980s, is said to function in both reduced and oxidized forms. It may neutralize free radicals in both the watery and fatty regions of cells and fortify the antioxidant power of vitamins C (water soluble) and E (fat soluble). It’s also been said to extend the metabolic lifespan of glutathione (a tripeptide essential to the metabolism of nutrients in cells and one that plays a major role in dissolving toxic substances in the liver) and coenzyme Q10 (a vitamin-like enzymatic cofactor needed for cells to produce energy). Supplemental forms of alpha-lipoic acid are easily absorbed into the bloodstream and may cross the blood-brain barrier.

Alpha-lipoic acid benefits; claims

Research indicates that ALA supplementation may slow age-related heart problems and brain degeneration, and help boost the physiological strength and cognitive function of older persons – hence its reference as an anti-aging nutrient. ALA may also stave off age-related macular degeneration and, when added to cosmetic creams and face masks, alpha-lipoic acid may enhance the elasticity and youthful appearance of skin.

Benefits of ALA supplementation may include:

o A reduction of oxidative stress and circulating free radicals in the body

o Improved heart and artery health

o Enhanced immune system strength and brain function

o Blood glucose regulation and balanced cholesterol

o Detoxification of the liver

o A healthy neural system

Alpha-lipoic acid side effects, safety and toxicity

Alpha-lipoic acid is said to be safe in doses ranging from 100 mg to 400 mg daily.* It may also be toxic, and even fatal, in doses as high as 1,800 mg a day.* Excessive doses of alpha-lipoic acid have been known to cause stomach upset and nausea and may lead to dangerously low blood glucose levels. The frequency and strength of ALA supplementation is typically based on the reason for treatment.

It is advisable to consult a physician prior to ALA supplementation if you’re:

o Taking any type of prescription medicine

o Allergic to any prescription or over-the-counter medicine or dietary supplement

o Pregnant or plan to become pregnant

o Nursing

o Suffering from any type of cardiovascular, heart, blood or arterial disorder

Though alpha-lipoic acid appears to be safe, the effects of long-term use have yet to be fully explored. Contraindications may exist, as might adverse reactions with certain medications or supplement regimens.

Research shows that the potency of alpha-lipoic acid may be diminished if mixed with certain compounds such as thiamine.

*Statement not evaluated by FDA

Clinical studies and alpha-lipoic acid research

The majority of current research available focuses on the impact of alpha-lipoic acid on rodents in the laboratory. ALA research has found that alpha-lipoic acid supplementation may aid inflammation in rats and reduce oxidative stress. It may also help to metabolize glucose and regulate blood sugar in mice.

Because oxidative damage is shown to be a major factor in the decline of physiological function in older persons, ALA’s potential in fighting immune disorders may be far reaching, as ALA has been found to protect cells from oxidative damage in older rats. It’s also been shown to suppress collagen-induced arthritis in mice and to slow retinal degeneration. Rodent studies suggest that ALA may improve epidermal blood flow and aid nerve damage caused by high blood glucose.

As a result of aggressive testing in the lab, alpha-lipoic acid is being studied for its potential in fighting human disorders as the cellular level. Alpha-lipoic acid research, however, is in the nascent stage, and the long-term potential of ALA supplementation in human health is relatively unknown.

Alpha-lipoic acid efficacy and the FDA

ALA is considered a dietary supplement in the U.S. and is neither regulated nor inspected by the FDA. As a result, there’s no guarantee to the purity, safety or strength of alpha-lipoic acid supplements. Research has revealed ALA benefits in rodents, but effective human clinical studies remain in the distance.

Laboratory tests in 2007 found that certain ALA supplements contained less alpha-lipoic acid than indicated on the label.

For more information on Alpha Lipoic Acid, visit www.VitaCost.com/Supplements/Alpha-Lipoic-Acid-ALA

References

1. All About alpha-lipoic acid. Frequently asked questions. The Complementary and Alternative Medicine Information Source Book. Edition 1, 2001 p159.

2. [alpha ]-Lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.(Author abstract)(Report) Meltem Kolgazi, Nermina Jahovic, Meral Yuksel, Feriha Ercan, Lnci Alican. Journal of Gastroenterology and Hepatology. Nov 2007 v22 i11 p1859 (7).

3. Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. (Author abstract)(Report) Clinical and Experimental Dermatology. Nov 2007 v32 i6 p631 (6).

4. The effect of [alpha ]-lipoic acid on symptoms and skin blood flow in diabetic neuropathy.(Author abstract)(Report) H.Y. Jin, S.J. Joung, J.H. Park, H.S. Baek, T.S. Park. Diabetic Medicine. Sept 2007 v24 i9 p1034(5).

5. Mitochondrial Aging and the Beneficial Role of [alpha]-Lipoic Acid. (Author abstract) A. R. Palaniappan, A. Dai. Neurochemical Research. Sept 2007 v32 i9 p1552 (7).

6. Wellness Guide to Dietary Supplements. UC Berkeley wellnessletter.com. 2007.

7. New alpha-lipoic acid from Aquanova Nutraceuticals International. July 2007 pNA.

8. ConsumerLab.com tests alpha lipoic acid supplements Nutraceuticals World. July-August 2007 v10 i7 p14 (1).

9. Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice. Eun Young Lee, Chang-Keun Lee, Ki-Up Lee, Joong Yeol Park, Kyung-Ja Cho, You Sook Cho, Hee Ran Lee, Se Hwan Moon, Hee-Bom Moon, Bin Yoo. Rheumatology International. Jan 2007 v27 i3 p225 (9).

10. Alpha-lipoic acid. Alternative Medicine Review. Sept 2006 v11 i3 p232 (6).

P90X2 Review – The Next Evolution in Fitness

The sequel to Beachbody’s widely-acclaimed P90X workout system, P90X2 will definitely push your body’s limits to new levels with its even more intense workouts, all condensed into a 5-days-a-week, 90-days-in-total workout system. P90X2 is Tony Horton’s solution to those seeking sculpted bodies, and have already completed his previous 90-day P90X workout. Take note – this new workout program is not for those who have yet to complete the original P90X workout. It is not recommended for those who have not exercised for a long in awhile or have just begun their fitness journey – it is an advanced workout system, after all.

P90X2 review – What exactly is it?

P90X’s sequel makes full use of what P90X has maintained as the core philosophy of its workout system – muscle confusion. Through muscles confusion, your muscles are overloaded, recuperated and overloaded again and again, leading to the build-up of true, lean muscle mass in the shortest time possible. On that note, Beachbody promises your body will change for the better, with less fat, lean muscles and more energy. Also, you’ll be able to customize your workouts as well to focus on either strength, agility or a balance of both.

P90X2 review – What goes into the workout?

There are a total of 3 phases to P90X 2:

Phase 1: Foundation

Phase 1 of P90X2 focuses on the foundations of your body – your core muscles, and thus your balance. Here, you will be exposed to instability exercises that force you to use the full potential of your core muscles to stabilize your body, such as the X2 core. This is a crucial part of your training – phase 1 will build the core strength and stability needed for the next 2 phases.

Phase 2: Strength

Here, P90X 2 revives a killer from P90X – the Plyocide. Focusing on plyometric (i.e. explosive power coming from a combination of strength and speed), this exercise will have you working up a sweat as you train your fast-twitch muscles. You’ll also be exposed to more instability workouts like X2 Chest/Back and Balance, which will focus on building the respective muscle group while further building on your core muscles’ strength.

Phase 3: Performance

The last phase of P90X2 focuses on further optimizing your body’s potential through Post Activation Potentiation (P.A.P). P.A.P workouts such as P.A.P Upper will combine strength training with plyometric training – this workout is not for beginners, once again, but advanced participants will reap tremendous benefits from this phase in the form of increased cardiovascular performance and plyometric potential.

P90X2 Workouts

Here is a complete list of all the new workout DVDs:

– X2 Core
– Plyocide
– X2 Recovery + Mobility
– X2 Total Body
– X2 Yoga
– Balance + Power
– Chest and Back + Balance
– X2 Shoulders + Arms
– Base and Back
– PAP Lower
– PAP Upper
– X2 Ab Ripper
– V Sculpt + Tris
– X2 Chest + Shoulders

The system also comes with the workout guide and a revamped nutrition guide, including a vegan option.

P90X2 Equipment

With new workouts and new moves comes new equipment. The basic equipment you will need to complete the workouts are resistance bands or dumbbells and a pull-up bar. Here is a list of optional but highly recommended tools that will also be feature in the new workouts:

  1. Balance ball
  2. Medicine balls
  3. Yoga mat
  4. Foam rollers
  5. Yoga blocks
  6. Push up bars

P90X2 Review – Conclusion

It is clear that P90X graduates will benefit tremendously from the workout – its emphasis on core muscles and further optimizing of performance will help these graduates achieve even better fitness results with P90X2. This is your chance to ‘bring it’ again and take your physical abilities to the next level.

Discover The Ideal Pharmacy Stores Through Online Pharmacy Reviews

Online products and services reviews are one way in which consumers can protect themselves from illegal traders who sell counterfeit products such as fake medication. With drug and medicines administration, there are illegal firms that operate without following the stipulated drug administration ethics and the law set to protect consumers. Reckless sale of medicines and medical drugs Puts consumers at risk. Online pharmacy reviews provides resourceful information, which helps in guiding consumers to determine the legitimate and illegitimate pharmacies. This ensures that they only deal with those pharmacy stores, which have been applauded by consumers.

There are pharmacy scams, which take place. These scams entail dispensation of drugs that are not tested and approved. Such drugs can be harmful and dangerous to humans and therefore, need to be tested and accepted before they are availed for sale. However, there are unscrupulous business minded persons who defy this requirement and go ahead to buy and such medicines and drugs which are not certified and sell over-the-counter. This exposes those who consume the drugs to greater risks such as contracting diseases and health complications. Nonetheless, online pharmacy reviews have assisted many customers who have been wondering where they can buy medicines that are approved.

Fake medication can be a source of problems that can linger around for many years. There are people who have developed serious health complications such as cancer, liver problems like cirrhosis and pancreas malfunction due to use of uncertified medications. This is not only costly but it also threatens the life of the consumers. The consumers who buy drugs from drug dispensing stores that operate in black market only risk their life. With increased proliferation of uncertified drugs and fake medication, it is certain that a collective responsibility is required by the drugs and medicines sellers, government departments and the consumers in order to offer viable medicine dispensation and sale practices.

There has been an increase in consumer complaints arising from the consumption of medicines, which have not been tested and permitted as fit for consumption. There are many licensed and certified pharmacies you can get on the Internet. These pharmacy stores carry through consultation to determine the kind of drug, which you need to take. You can buy your medication such as erectile dysfunction medicines including Viagra and Levitra. You can also purchase medications for depression, obesity and hair loss from these primed pharmacy stores and this helps in preventing pharmacy scams. With these stores, you need to present a prescription from a certified doctor or clinical personnel in order to be dispensed the drug.

This helps in curbing irresponsible consumption of drugs and medicines. You can get online consultations with a GMC registered UK doctor and get your prescription and advice on where to buy the certified medicines. This helps reduce the consumer complaints. Then again, the consumers must ethically observe all the rules, regulations, guidelines and law that have been set by the state government on drug dispensation. Similarly, the pharmacy stores should not sell drugs and medicines that require doctor’s prescription without the prescription.